Trifluoroacetic acid → N-(5-(4-amino-3-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-iodonicotinamide

HRID 950175Notes

Reaction equation

HRID 950175 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[NH:10][c:11]1[c:12]([Cl:39])[cH:13][c:14](-[c:17]2[c:18]([O:33][CH2:34][C:35]([F:36])([F:37])[F:38])[n:19][cH:20][c:21]([NH:23][C:24](=[O:25])[c:26]3[cH:27][n:28][cH:29][c:30]([I:32])[cH:31]3)[cH:22]2)[cH:15][cH:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:40]1.[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[NH2:10][c:11]1[c:12]([Cl:39])[cH:13][c:14](-[c:17]2[c:18]([O:33][CH2:34][C:35]([F:36])([F:37])[F:38])[n:19][cH:20][c:21]([NH:23][C:24](=[O:25])[c:26]3[cH:27][n:28][cH:29][c:30]([I:32])[cH:31]3)[cH:22]2)[cH:15][cH:16]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67282185{2-Chloro-4-[5-[(5-iodo-pyridine-3-carbonyl)-amino]-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-phenyl}-carbamic acid benzyl ester

Product 1

HCID 56961948N-(5-(4-amino-3-chlorophenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-5-iodonicotinamide

Sources & evidence

ORD record
ord-cb578c6e374f4a93935c2178186104e0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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