Dichloromethane → 4-[[4-[3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl]aniline
Reaction equation
[Cl:42][CH2:43][Cl:44].[F:8][C:9]([c:10]1[n:11][n:12][c:13]2[n:14]1[n:15][c:16]([N:19]1[CH2:20][CH2:21][N:22]([CH2:25][c:26]3[cH:27][cH:28][c:29]([NH:32][C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[cH:30][cH:31]3)[CH2:23][CH2:24]1)[cH:17][cH:18]2)([F:40])[F:41].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[F:8][C:9]([c:10]1[n:11][n:12][c:13]2[n:14]1[n:15][c:16]([N:19]1[CH2:20][CH2:21][N:22]([CH2:25][c:26]3[cH:27][cH:28][c:29]([NH2:32])[cH:30][cH:31]3)[CH2:23][CH2:24]1)[cH:17][cH:18]2)([F:40])[F:41]Participants
4
Sources & evidence
- ORD record
- ord-df7a94c1685b459aae0d3775e837b12b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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