Sodium ion → tert-Butyl 4-((2-methoxy-5-nitrobenzyloxy)methyl)-4-phenylpiperidine-1-carboxylate

HRID 950314Notes

Reaction equation

HRID 950314 reaction equation
[Br:1][CH2:2][c:3]1[c:4]([O:12][CH3:13])[cH:5][cH:6][c:7]([N+:9](=[O:10])[O-:11])[cH:8]1.[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[H-:35].[Na+:36].[OH2:42].[OH:14][CH2:15][C:16]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1>>[CH2:2]([c:3]1[c:4]([O:12][CH3:13])[cH:5][cH:6][c:7]([N+:9](=[O:10])[O-:11])[cH:8]1)[O:14][CH2:15][C:16]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 775162-(Bromomethyl)-1-methoxy-4-nitrobenzeneHCID 166653HydrideHCID 9994433Tert-butyl 4-(hydroxymethyl)-4-phenylpiperidine-1-carboxylate

Product 1

HCID 58993459tert-Butyl 4-((2-methoxy-5-nitrobenzyloxy)methyl)-4-phenylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-8f28a9020faf4be0b7d594771abb2334
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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