Diisopropylamine → (5-bromo-2-fluoro-pyridin-3-yl)-(2-ethyl-2H-pyrazol-3-yl)-methanone

HRID 950501Notes

Reaction equation

HRID 950501 reaction equation
[Br:13][c:14]1[cH:15][cH:16][c:17]([F:20])[n:18][cH:19]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:21][O:22][N:23]([C:24](=[O:25])[c:26]1[n:27]([CH2:31][CH3:32])[n:28][cH:29][cH:30]1)[CH3:33].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[Br:13][c:14]1[cH:15][c:16]([C:24](=[O:25])[c:26]2[n:27]([CH2:31][CH3:32])[n:28][cH:29][cH:30]2)[c:17]([F:20])[n:18][cH:19]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 27831685-Bromo-2-fluoropyridineHCID 577316551-ethyl-N-methoxy-N-methyl-1H-pyrazole-5-carboxamideHCID 178418339Butyllithium

Product 1

HCID 57731543(5-bromo-2-fluoro-pyridin-3-yl)-(2-ethyl-2H-pyrazol-3-yl)-methanone

Sources & evidence

ORD record
ord-ac683af62cc241c4ad80f38c269e9d94
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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