Hydrochloric Acid → Ethyl 2-(2-amino-5-chloroanilino)benzo[b]thiophene-3-carboxylate

HRID 950534Notes

Reaction equation

HRID 950534 reaction equation
[C:31](=[O:32])([O-:33])[O-:34].[CH3:37][CH2:38][OH:39].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:23]([O-:24])=[O:25])[c:6]([NH:7][c:8]2[c:9]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:10]3[c:11]([s:12]2)[cH:13][cH:14][cH:15][cH:16]3)[cH:22]1.[ClH:40].[K+:35].[K+:36].[OH2:26].[OH2:27].[Sn:28]([Cl:29])[Cl:30]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH2:23])[c:6]([NH:7][c:8]2[c:9]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:10]3[c:11]([s:12]2)[cH:13][cH:14][cH:15][cH:16]3)[cH:22]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 702EthanolHCID 813Potassium Cation2×HCID 962Water2×HCID 19660Carbonate IonHCID 24479Stannous ChlorideHCID 18422161Ethyl 2-(5-chloro-2-nitroanilino)benzo[b]thiophene-3-carboxylate

Product 1

HCID 18422169Ethyl 2-(2-amino-5-chloroanilino)benzo[b]thiophene-3-carboxylate

Sources & evidence

ORD record
ord-ea65d61b22614a8eb227d16937beb429
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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