Acetonitrile → [3,5-bis(trifluoromethyl)phenyl]-[2-(1H-indol-3-ylmethyl)-4-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)piperazin-1-yl]methanone

HRID 950540Notes

Reaction equation

HRID 950540 reaction equation
[CH3:55][C:56]#[N:57].[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH:9]([CH2:22][c:23]3[cH:24][nH:25][c:26]4[cH:27][cH:28][cH:29][cH:30][c:31]34)[CH2:10][N:11]([CH2:14][CH2:15][CH2:16][O:17][S:18]([CH3:19])(=[O:20])=[O:21])[CH2:12][CH2:13]2)[cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[cH:34]1)([F:39])[F:40].[NH:41]1[CH2:42][CH2:43][C:44]2([CH2:45][CH2:46][c:47]3[cH:48][cH:49][cH:50][cH:51][c:52]32)[CH2:53][CH2:54]1>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH:9]([CH2:22][c:23]3[cH:24][nH:25][c:26]4[cH:27][cH:28][cH:29][cH:30][c:31]34)[CH2:10][N:11]([CH2:14][CH2:15][CH2:16][N:41]3[CH2:42][CH2:43][C:44]4([CH2:45][CH2:46][c:47]5[cH:48][cH:49][cH:50][cH:51][c:52]54)[CH2:53][CH2:54]3)[CH2:12][CH2:13]2)[cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[cH:34]1)([F:39])[F:40]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 156376162,3-Dihydrospiro(indene-1,4'-piperidine)HCID 1785052943-[4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)piperazin-1-yl]propyl methanesulfonate

Product 1

HCID 178519643[3,5-bis(trifluoromethyl)phenyl]-[2-(1H-indol-3-ylmethyl)-4-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)piperazin-1-yl]methanone

Sources & evidence

ORD record
ord-78b1c7f98f83490b9f51b0608848d697
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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