Bromide ion → 2-Bromo-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester

HRID 950553Notes

Reaction equation

HRID 950553 reaction equation
[Br-:29].[BrH:30].[N:25]([O-:26])=[O:27].[NH2:1][c:2]1[s:3][c:4]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[c:5]([C:7]([F:8])([F:9])[F:10])[n:6]1.[Na+:28].[OH2:31].[OH:21][N+:22](=[O:23])[O-:24].[P:16](=[O:17])([OH:18])([OH:19])[OH:20]>>[c:2]1([Br:29])[s:3][c:4]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[c:5]([C:7]([F:8])([F:9])[F:10])[n:6]1

Participants

9

Reactant 8

HCID 259Bromide ionHCID 260Hydrogen BromideHCID 923Sodium ionHCID 944Nitric AcidHCID 946NitriteHCID 962WaterHCID 1004Phosphoric AcidHCID 676565-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester

Product 1

HCID 132827592-Bromo-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-022221c5547b4fa09e5c47e3f635dd24
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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