Dichloromethane → N-(4-(3-(1,2,3,6-Tetrahydropyridin-4-YL)pyridin-2-yloxy)phenyl)benzo[D]thiazol-2-amine

HRID 950575Notes

Reaction equation

[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43].[s:1]1[c:2]([NH:10][c:11]2[cH:12][cH:13][c:14]([O:15][c:16]3[n:17][cH:18][cH:19][cH:20][c:21]3[C:22]3=[CH:23][CH2:24][N:25]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:26][CH2:27]3)[cH:35][cH:36]2)[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2>>[s:1]1[c:2]([NH:10][c:11]2[cH:12][cH:13][c:14]([O:15][c:16]3[n:17][cH:18][cH:19][cH:20][c:21]3[C:22]3=[CH:23][CH2:24][NH:25][CH2:26][CH2:27]3)[cH:35][cH:36]2)[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 59327027tert-butyl 4-(2-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 59326929N-(4-(3-(1,2,3,6-Tetrahydropyridin-4-YL)pyridin-2-yloxy)phenyl)benzo[D]thiazol-2-amine

Sources & evidence

ORD record: ord-a5217b66b77b466bb800d2899e125617
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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