Tetrahydrofuran → 4-[(4-Bromo-3-fluorophenyl)(cycloheptylidene)methyl]phenol

HRID 950801Notes

Reaction equation

HRID 950801 reaction equation
[Br:1][c:2]1[c:3]([F:17])[cH:4][c:5]([C:8](=[O:9])[c:10]2[cH:11][cH:12][c:13]([OH:16])[cH:14][cH:15]2)[cH:6][cH:7]1.[C:18]1(=[O:25])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1.[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[Zn:31]>>[Br:1][c:2]1[c:3]([F:17])[cH:4][c:5]([C:8]([c:10]2[cH:11][cH:12][c:13]([OH:16])[cH:14][cH:15]2)=[C:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 10400CycloheptanoneHCID 23994ZincHCID 68654588(4-Bromo-3-fluorophenyl)(4-hydroxyphenyl)methanone

Product 1

HCID 686544904-[(4-Bromo-3-fluorophenyl)(cycloheptylidene)methyl]phenol

Sources & evidence

ORD record
ord-930bef6976b540a79aaaeb3c34773c82
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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