Dichloromethane → N-Methyl-3-(methyloxy)-4-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)benzamide

HRID 951037Notes

Reaction equation

[CH3:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([O:30][CH3:31])[c:8]([O:11][c:12]2[cH:13][c:14]3[c:15]([cH:28][cH:29]2)[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[cH:9][cH:10]1.[Cl:39][CH2:40][Cl:41].[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[CH3:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([O:30][CH3:31])[c:8]([O:11][c:12]2[cH:13][c:14]3[c:15]([cH:28][cH:29]2)[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:9][cH:10]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 574402991,1-Dimethylethyl 7-{[4-[(methylamino)carbonyl]-2-(methyloxy)phenyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Product 1

HCID 57440300N-Methyl-3-(methyloxy)-4-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yloxy)benzamide

Sources & evidence

ORD record: ord-cafdf084f8914990b7af2f11de78843d
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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