Methanol → Tert-butyl 3-(4-amino-2-methoxyphenoxy)azetidine-1-carboxylate

HRID 951205Notes

Reaction equation

HRID 951205 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([O:12][c:13]2[c:14]([O:22][CH3:23])[cH:15][c:16]([N+:19]([O-:20])=[O:21])[cH:17][cH:18]2)[CH2:11]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:24][OH:25].[CH3:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([O:12][c:13]2[c:14]([O:22][CH3:23])[cH:15][c:16]([NH2:19])[cH:17][cH:18]2)[CH2:11]1

Participants

5

Reactant 4

HCID 887MethanolHCID 1140TolueneHCID 8028TetrahydrofuranHCID 46835555Tert-butyl 3-(2-methoxy-4-nitrophenoxy)azetidine-1-carboxylate

Product 1

HCID 46835556Tert-butyl 3-(4-amino-2-methoxyphenoxy)azetidine-1-carboxylate

Sources & evidence

ORD record
ord-7914fd274958465c88b396136581108e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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