Diisopropylamine → Methyl 2-fluoro-2-pyridin-2-ylpropanoate

HRID 951402Notes

Reaction equation

HRID 951402 reaction equation
[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[F:21][N:22]([S:23]([c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)(=[O:30])=[O:31])[S:32]([c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)(=[O:39])=[O:40].[Li:8].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[n:9]1[c:10]([CH:15]([C:16](=[O:17])[O:18][CH3:19])[CH3:20])[cH:11][cH:12][cH:13][cH:14]1>>[n:9]1[c:10]([C:15]([C:16](=[O:17])[O:18][CH3:19])([CH3:20])[F:21])[cH:11][cH:12][cH:13][cH:14]1

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 588007N-FluorobenzenesulfonimideHCID 3028194LithiumHCID 54595201Methyl 2-(pyridin-2-yl)propanoate

Product 1

HCID 66881466Methyl 2-fluoro-2-pyridin-2-ylpropanoate

Sources & evidence

ORD record
ord-24647fd7936c457ea4c2d7f10c1a0dad
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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