Sodium ion → 3-Amino-1-cyclopropyl-6,7-difluoro-1H-quinazoline-2,4-dione

HRID 951428Notes

Reaction equation

HRID 951428 reaction equation
[CH3:40][N:41]([CH3:42])[CH:43]=[O:44].[CH:1]1([n:4]2[c:5](=[O:17])[nH:6][c:7](=[O:16])[c:8]3[cH:9][c:10]([F:15])[c:11]([F:14])[cH:12][c:13]23)[CH2:2][CH2:3]1.[H-:19].[N+:20]([c:21]1[cH:22][c:23]([N+:24]([O-:25])=[O:26])[cH:27][cH:28][c:29]1[O:30][NH2:31])([O-:32])=[O:33].[Na+:18].[O:34]1[CH2:35][CH2:36][O:37][CH2:38][CH2:39]1>>[CH:1]1([n:4]2[c:5](=[O:17])[n:6]([NH2:20])[c:7](=[O:16])[c:8]3[cH:9][c:10]([F:15])[c:11]([F:14])[cH:12][c:13]23)[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6228DimethylformamideHCID 312751,4-DioxaneHCID 87140O-(2,4-dinitrophenyl)hydroxylamineHCID 166653HydrideHCID 112764481-Cyclopropyl-6,7-difluoroquinazoline-2,4(1H,3H)-dione

Product 1

HCID 114821773-Amino-1-cyclopropyl-6,7-difluoro-1H-quinazoline-2,4-dione

Sources & evidence

ORD record
ord-b9d73187fce14031b3baa081aac9ce0c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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