Tetrahydrofuran → 4-Chloro-2-fluoro-5-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzylamine

HRID 951676Notes

Reaction equation

[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[Cl:1][c:2]1[cH:3][c:4]([F:32])[c:5]([C:6]#[N:7])[cH:8][c:9]1[NH:10][c:11]1[n:12][c:13]2[c:14]([n:15]1[CH3:16])[cH:17][c:18]([N:22]1[CH2:23][CH2:24][CH:25]([C:28]([F:29])([F:30])[F:31])[CH2:26][CH2:27]1)[c:19]([Cl:21])[cH:20]2>>[Cl:1][c:2]1[cH:3][c:4]([F:32])[c:5]([CH2:6][NH2:7])[cH:8][c:9]1[NH:10][c:11]1[n:12][c:13]2[c:14]([n:15]1[CH3:16])[cH:17][c:18]([N:22]1[CH2:23][CH2:24][CH:25]([C:28]([F:29])([F:30])[F:31])[CH2:26][CH2:27]1)[c:19]([Cl:21])[cH:20]2

Participants

Reactant 2

HCID 8028Tetrahydrofuran

HCID 866743494-Chloro-5-[5-chloro-1-methyl-6-(4-(trifluoromethyl)piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]-2-fluorobenzonitrile

Product 1

HCID 866743504-Chloro-2-fluoro-5-[5-chloro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzylamine

Sources & evidence

ORD record: ord-13abd9a01b3643f7869b40461843e482
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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