Dichloromethane → 4-{4-[(4'-Isopropyl-5-methyl-biphenyl-2-carbonyl)-amino]-phenyl}piperazine-1-carboxylic Acid Tert-Butyl Ester

HRID 951677Notes

Reaction equation

HRID 951677 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([NH2:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:50][CH2:51][N:52]([CH2:53][CH3:54])[CH2:55][CH3:56].[CH:21]([CH3:22])([CH3:23])[c:24]1[cH:25][cH:26][c:27](-[c:30]2[c:31]([C:37](=[O:38])[OH:39])[cH:32][cH:33][c:34]([CH3:36])[cH:35]2)[cH:28][cH:29]1.[Cl:57][CH2:58][Cl:59].[OH:40][n:41]1[c:42]2[c:43]([cH:44][cH:45][cH:46][cH:47]2)[n:48][n:49]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:37]([c:31]3[c:30](-[c:27]4[cH:26][cH:25][c:24]([CH:21]([CH3:22])[CH3:23])[cH:29][cH:28]4)[cH:35][c:34]([CH3:36])[cH:33][cH:32]3)=[O:38])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 11011301tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylateHCID 185454504'-Isopropyl-5-methyl-biphenyl-2-carboxylic acid

Product 1

HCID 540547824-{4-[(4'-Isopropyl-5-methyl-biphenyl-2-carbonyl)-amino]-phenyl}piperazine-1-carboxylic Acid Tert-Butyl Ester

Sources & evidence

ORD record
ord-d974c87345a74763ba6393c0f98c81c3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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