Trifluoroacetic acid → 6-Fluoro-7-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

HRID 951841Notes

Reaction equation

HRID 951841 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][CH2:6][CH2:7][O:8][NH:9][C:10](=[O:11])[c:12]1[c:13]([NH:23][c:24]2[c:25]([F:31])[cH:26][c:27]([I:30])[cH:28][cH:29]2)[c:14]([F:22])[c:15](=[O:21])[n:16]2[c:20]1[CH2:19][CH2:18][CH2:17]2.[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38]>>[OH:5][CH2:6][CH2:7][O:8][NH:9][C:10](=[O:11])[c:12]1[c:13]([NH:23][c:24]2[c:25]([F:31])[cH:26][c:27]([I:30])[cH:28][cH:29]2)[c:14]([F:22])[c:15](=[O:21])[n:16]2[c:20]1[CH2:19][CH2:18][CH2:17]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576898066-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-tert-butoxy-ethoxy)-amide

Product 1

HCID 426062046-Fluoro-7-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxamide

Sources & evidence

ORD record
ord-54462fc071554fdc98c3904a91d1b472
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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