反应详情

温度

100 °C

A mixture of 500 mg of 4-(4-fluorophenyl) methylaniline and 445 mg of bis(2-chloroethyl)amine hydrochloride was stirred at 100° C. for 2 hours, then gradually raised in temperature to 200° C. and then further stirred for 2 hours. This was then cooled to room temperature, then the product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5) to obtain the above-referenced compound (5) in an amount of 503 mg (yield of 75%).

1. temperaturegradually raised in temperature to 200° C.
2. stirringfurther stirred for 2 hours
3. temperatureThis was then cooled to room temperature
4. customthe product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5)