Dichloromethane → 1-(4-Methoxybenzyl)piperidin-4-amine

HRID 952174Notes

Reaction equation

HRID 952174 reaction equation
[CH2:31]([Cl:32])[Cl:33].[CH3:1][C:2]([N:5]([C:3](=[O:4])[O-:6])[CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][c:16]2[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]2)[CH2:13][CH2:14]1)([CH3:7])[CH3:8].[OH:24][C:25]([C:26]([F:27])([F:28])[F:29])=[O:30]>>[NH2:5][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][c:16]2[cH:17][cH:18][c:19]([O:22][CH3:23])[cH:20][cH:21]2)[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 867409101,1-Dimethylethyl1-[(4-methoxyphenyl)methyl]-4-piperidinylcarbamate

Product 1

HCID 126418411-(4-Methoxybenzyl)piperidin-4-amine

Sources & evidence

ORD record
ord-85fd2572e02e4bd4805a88add280b5e4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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