Tetrahydrofuran → 2-(2,6-Difluoro-4-methoxyphenyl)-1,1,1-trifluoropropan-2-ol
Reaction equation
[CH2:16]([Li:17])[CH2:18][CH2:19][CH3:20].[CH2:1]1[O:2][CH2:3][CH2:4][CH2:5]1.[CH3:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].[F:21][C:22]([C:23](=[O:24])[CH3:25])([F:26])[F:27].[F:6][c:7]1[cH:8][c:9]([F:15])[cH:10][c:11]([O:13][CH3:14])[cH:12]1>>[F:6][c:7]1[c:8]([C:23]([C:22]([F:21])([F:26])[F:27])([OH:24])[CH3:25])[c:9]([F:15])[cH:10][c:11]([O:13][CH3:14])[cH:12]1Participants
6
Sources & evidence
- ORD record
- ord-85a32371a3704603b79a09d12f426528
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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