Chlorodifluoromethane → [8-Chloro-4-difluoromethoxy-2-isopropyl-3-(4-pyrazol-1-ylbenzyl)quinolin-5-yloxy]acetic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3]([CH2:4][O:5][c:6]1[c:7]2[c:8](=[O:32])[c:9]([CH2:20][c:21]3[cH:22][cH:23][c:24](-[n:27]4[n:28][cH:29][cH:30][cH:31]4)[cH:25][cH:26]3)[c:10]([CH:17]([CH3:18])[CH3:19])[nH:11][c:12]2[c:13]([Cl:16])[cH:14][cH:15]1)=[O:33].[Cl:34][CH:35]([F:36])[F:37]>>[CH3:1][O:2][C:3]([CH2:4][O:5][c:6]1[c:7]2[c:8]([O:32][CH:35]([F:36])[F:37])[c:9]([CH2:20][c:21]3[cH:22][cH:23][c:24](-[n:27]4[n:28][cH:29][cH:30][cH:31]4)[cH:25][cH:26]3)[c:10]([CH:17]([CH3:18])[CH3:19])[n:11][c:12]2[c:13]([Cl:16])[cH:14][cH:15]1)=[O:33]Participants
3
Sources & evidence
- ORD record
- ord-1b06b7818bfd43d0a30cd6547a5161f7
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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