Dichloromethane → 2-[(4-{2-[(5-Ethylpyrimidin-2-yl)(4-morpholin-4-ylbenzyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([C:7]([CH3:8])([CH3:9])[S:10][c:11]1[s:12][cH:13][c:14]([CH2:16][CH2:17][N:18]([CH2:19][c:20]2[cH:21][cH:22][c:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[cH:24][cH:25]2)[c:32]2[n:33][cH:34][c:35]([CH2:38][CH3:39])[cH:36][n:37]2)[n:15]1)=[O:40].[Cl:48][CH2:49][Cl:50].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[O:5]=[C:6]([C:7]([CH3:8])([CH3:9])[S:10][c:11]1[s:12][cH:13][c:14]([CH2:16][CH2:17][N:18]([CH2:19][c:20]2[cH:21][cH:22][c:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[cH:24][cH:25]2)[c:32]2[n:33][cH:34][c:35]([CH2:38][CH3:39])[cH:36][n:37]2)[n:15]1)[OH:40]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-ae6745ae59604c61b1a8d41e47d4cf8b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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