Methanol → 1-(Propan-2-yl)piperidin-4-amine

HRID 952436Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][CH2:10][N:11]([CH:14]([CH3:15])[CH3:16])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:17].[CH3:25][OH:26].[OH:18][C:19]([C:20]([F:21])([F:22])[F:23])=[O:24]>>[NH2:7][CH:8]1[CH2:9][CH2:10][N:11]([CH:14]([CH3:15])[CH3:16])[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 887Methanol

HCID 6422Trifluoroacetic acid

HCID 20801240tert-Butyl (1-isopropylpiperidin-4-yl)carbamate

Product 1

HCID 31633331-(Propan-2-yl)piperidin-4-amine

Sources & evidence

ORD record: ord-4cbfeae011f045359256299fd3523f86
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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