Sodium ion → 1-[2-Fluoro-5-bromobenzyloxy]-3-[1-(t-butoxycarbonyl)piperidin-3-yl]propane

HRID 952611Notes

Reaction equation

HRID 952611 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:14][CH2:15][CH2:16][Br:17])[CH2:11][CH2:12][CH2:13]1.[CH3:32][N:33]([CH3:34])[CH:35]=[O:36].[F:20][c:21]1[c:22]([CH2:23][OH:24])[cH:25][c:26]([Br:29])[cH:27][cH:28]1.[H-:30].[I-:19].[Na+:18].[Na+:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:14][CH2:15][CH2:16][O:24][CH2:23][c:22]2[c:21]([F:20])[cH:28][cH:27][c:26]([Br:29])[cH:25]2)[CH2:11][CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 30165Iodide IonHCID 166653HydrideHCID 2773352(5-Bromo-2-fluorophenyl)methanolHCID 18515798tert-Butyl 3-(3-bromopropyl)piperidine-1-carboxylate

Product 1

HCID 211959541-[2-Fluoro-5-bromobenzyloxy]-3-[1-(t-butoxycarbonyl)piperidin-3-yl]propane

Sources & evidence

ORD record
ord-d349cf49ac9849a29234d0f4c52d425c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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