1,4-Dioxaspiro[4.5]decan-8-one → N-(1-(4-hydroxy-4-(2-methylthiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

HRID 952745Notes

Reaction equation

[Br:15][c:16]1[s:17][c:18]([CH3:19])[n:20][cH:21]1.[NH:33]1[CH2:34][CH:35]([NH:37][C:38]([CH2:39][NH:40][c:41]2[n:42][cH:43][n:44][c:45]3[cH:46][cH:47][c:48]([C:51]([F:52])([F:53])[F:54])[cH:49][c:50]23)=[O:55])[CH2:36]1.[O:22]1[C:23]2([CH2:24][CH2:25][C:26](=[O:27])[CH2:28][CH2:29]2)[O:30][CH2:31][CH2:32]1.[OH:1][C:2]1([c:9]2[cH:10][n:11][c:12]([CH3:14])[s:13]2)[CH2:3][CH2:4][C:5](=[O:8])[CH2:6][CH2:7]1>>[OH:1][C:2]1([c:9]2[cH:10][n:11][c:12]([CH3:14])[s:13]2)[CH2:3][CH2:4][CH:5]([N:33]2[CH2:34][CH:35]([NH:37][C:38]([CH2:39][NH:40][c:41]3[n:42][cH:43][n:44][c:45]4[cH:46][cH:47][c:48]([C:51]([F:52])([F:53])[F:54])[cH:49][c:50]34)=[O:55])[CH2:36]2)[CH2:6][CH2:7]1