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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 952745Generated: October 30, 2026

1,4-Dioxaspiro[4.5]decan-8-one → N-(1-(4-hydroxy-4-(2-methylthiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

https://huagongshe.com/reaction/952745

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxaspiro[4.5]decan-8-oneHCID 567415—
Reactant5-Bromo-2-methyl-1,3-thiazoleHCID 13228663—
ReactantHCID 59017431HCID 59017431—
ReactantN-(azetidin-3-yl)-2((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamideHCID 68003594—
ProductN-(1-(4-hydroxy-4-(2-methylthiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamideHCID 68004012—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-7a9b9ec6c9234a73a4a58ea016c91c0b
Source noteValidation data from https://doi.org/10.1039/C8SC04228D