Dichloromethane → 3-{[3-(Aminomethyl)-6-(difluoromethyl)-2-fluorophenyl]oxy}-5-chlorobenzonitrile
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]([O:10][c:11]2[c:12]([F:29])[c:13]([CH2:20][NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[cH:14][cH:15][c:16]2[CH:17]([F:18])[F:19])[cH:5][c:6]([C:8]#[N:9])[cH:7]1.[Cl:37][CH2:38][Cl:39].[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36]>>[Cl:1][c:2]1[cH:3][c:4]([O:10][c:11]2[c:12]([F:29])[c:13]([CH2:20][NH2:21])[cH:14][cH:15][c:16]2[CH:17]([F:18])[F:19])[cH:5][c:6]([C:8]#[N:9])[cH:7]1Participants
4
Sources & evidence
- ORD record
- ord-a614611dcdc841d49b2e8e14da57b90c
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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