Trifluoroacetic acid → 3-(hydroxymethyl)-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutylacetonitrile
Reaction equation
[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38].[OH:1][CH2:2][CH:3]1[CH2:4][C:5]([n:7]2[n:8][cH:9][c:10](-[c:12]3[c:13]4[c:14]([n:15][cH:16][n:17]3)[n:18]([CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[cH:19][cH:20]4)[cH:11]2)([CH2:29][C:30]#[N:31])[CH2:6]1>>[OH:1][CH2:2][CH:3]1[CH2:4][C:5]([n:7]2[n:8][cH:9][c:10](-[c:12]3[c:13]4[c:14]([n:15][cH:16][n:17]3)[nH:18][cH:19][cH:20]4)[cH:11]2)([CH2:29][C:30]#[N:31])[CH2:6]1Participants
3
Sources & evidence
- ORD record
- ord-bf31364a97404e7fa818c73c7deab5e5
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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