Dichloromethane → 5-methyl-4-piperidin-4-yl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 95312Notes

Reaction equation

HRID 95312 reaction equation
[CH3:8][CH:9]1[CH2:10][CH2:11][c:12]2[n:13][cH:14][n:15][c:16]([CH:18]3[CH2:19][CH2:20][N:21]([C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:22][CH2:23]3)[c:17]21.[Cl:31][CH2:32][Cl:33].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[CH3:8][CH:9]1[CH2:10][CH2:11][c:12]2[n:13][cH:14][n:15][c:16]([CH:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[c:17]21

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67436184tert-butyl 4-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperidine-1-carboxylate

Product 1

HCID 674383225-methyl-4-piperidin-4-yl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Sources & evidence

ORD record
ord-72244e24a0304d9cafa67e271ab9fd72
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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