Tetrahydrofuran → Tert-butyl 4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate

HRID 953134Notes

Reaction equation

HRID 953134 reaction equation
[CH3:2][CH2:3][CH2:4][CH2:5][N+:6]([CH2:7][CH2:8][CH2:9][CH3:10])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18].[F-:1].[F:19][C:20]([F:21])([F:22])[Si:23]([CH3:24])([CH3:25])[CH3:26].[O:27]=[C:28]1[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:32][CH2:33]1.[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[F:19][C:20]([F:21])([F:22])[C:28]1([OH:27])[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:32][CH2:33]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22061329Tert-butyl 4-hydroxy-4-(trifluoromethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-9f2c99210f1a4998803cf29a624c4382
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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