Dichloromethane → 4-hydroxy-2-phenethyl-2-phenyl-5-phenylsulfanyl-3H-pyran-6-one

HRID 953198Notes

Reaction equation

HRID 953198 reaction equation
[Br:1][C:2]1=[C:7]([OH:8])[CH2:6][C:5]([CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[O:4][C:3]1=[O:23].[CH2:31]1[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]1.[Cl:37][CH2:38][Cl:39].[SH:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[C:2]1([S:24][c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)=[C:7]([OH:8])[CH2:6][C:5]([CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[O:4][C:3]1=[O:23]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 7969ThiophenolHCID 8082PiperidineHCID 547216393-bromo-5,6-dihydro-4-hydroxy-6-phenyl-6-(2-phenylethyl)-2H-pyran-2-one

Product 1

HCID 546890014-hydroxy-2-phenethyl-2-phenyl-5-phenylsulfanyl-3H-pyran-6-one

Sources & evidence

ORD record
ord-93a619f765394888ac2b5309c8500d66
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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