Dichloromethane → 2,3-Dihydro-1H-isoindole-5-carbonitrile

HRID 953332Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17]#[N:18])[cH:14][c:15]2[CH2:16]1)([CH3:5])([CH3:6])[CH3:7].[Cl:26][CH2:27][Cl:28].[OH:19][C:20]([C:21]([F:22])([F:23])[F:24])=[O:25]>>[NH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17]#[N:18])[cH:14][c:15]2[CH2:16]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 18630967tert-Butyl 5-cyano-1,3-dihydro-2H-isoindole-2-carboxylate

Product 1

HCID 179862802,3-Dihydro-1H-isoindole-5-carbonitrile

Sources & evidence

ORD record: ord-7acda22c874744868b474ea2f55a4b95
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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