Potassium Cation → Tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

HRID 953333Notes

Reaction equation

HRID 953333 reaction equation
[Br:1][CH2:2][c:3]1[n:4][c:5]([Cl:13])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1.[CH3:35][C:36]([CH3:37])([O-:38])[CH3:39].[K+:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[OH2:46].[OH:14][CH2:15][C:16]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1>>[CH2:2]([c:3]1[n:4][c:5]([Cl:13])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)[O:14][CH2:15][C:16]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1

Participants

7

Reactant 6

HCID 813Potassium CationHCID 962WaterHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 9994433Tert-butyl 4-(hydroxymethyl)-4-phenylpiperidine-1-carboxylateHCID 534037392-(Bromomethyl)-6-chloro-4-(trifluoromethyl)pyridine

Product 1

HCID 57557581Tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-f5ca91f5ae714d1fab74d0269c6e1be2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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