Dichloromethane → (5-Bromo-pyrimidin-2-yl)-piperidin-3-ylamine

HRID 953694Notes

Reaction equation

HRID 953694 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([NH:14][c:15]2[n:16][cH:17][c:18]([Br:21])[cH:19][n:20]2)[CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:29][CH2:30][Cl:31].[F:22][C:23]([F:24])([F:25])[C:26]([OH:27])=[O:28]>>[NH:8]1[CH2:9][CH:10]([NH:14][c:15]2[n:16][cH:17][c:18]([Br:21])[cH:19][n:20]2)[CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 581854853-(5-Bromo-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 63872105(5-Bromo-pyrimidin-2-yl)-piperidin-3-ylamine

Sources & evidence

ORD record
ord-71c1471dcb67410fb911fab3b21b7fa4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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