Acetate → 2-Fluoro-5-phenylamino-terephthalic Acid Dimethyl Ester

HRID 953869Notes

Reaction equation

HRID 953869 reaction equation
[Br:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[C:24](=[O:25])([O-:26])[O-:27].[CH3:1][O:2][C:3]([c:4]1[c:5]([NH2:15])[cH:6][c:7]([C:8](=[O:9])[O:10][CH3:11])[c:12]([F:14])[cH:13]1)=[O:16].[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[Cs+:28].[Cs+:29].[O-:31][C:32]([CH3:33])=[O:34].[O-:35][C:36]([CH3:37])=[O:38].[Pd+2:30]>>[CH3:1][O:2][C:3]([c:4]1[c:5]([NH:15][c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[cH:6][c:7]([C:8](=[O:9])[O:10][CH3:11])[c:12]([F:14])[cH:13]1)=[O:16]

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 7961BromobenzeneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 16748146Dimethyl 2-amino-5-fluoroterephthalate

Product 1

HCID 167486382-Fluoro-5-phenylamino-terephthalic Acid Dimethyl Ester

Sources & evidence

ORD record
ord-883740baa99c46519ae30becff5b3d8a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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