Hydrochloric Acid → 5-Amino-4-(2-chlorophenyl)-2-ethylthieno[2,3-b]pyridine

HRID 954017Notes

Reaction equation

HRID 954017 reaction equation
[CH:30]([Cl:31])([Cl:32])[Cl:33].[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][cH:12][c:13]2[N+:14]([O-:15])=[O:16])[s:17][c:18]([CH2:20][CH3:21])[cH:19]3)[cH:4][cH:5][cH:6][cH:7]1.[ClH:22].[Na+:29].[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1.[OH-:28].[OH2:23].[OH2:24].[OH2:34].[Sn:25]([Cl:26])[Cl:27]>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][cH:12][c:13]2[NH2:14])[s:17][c:18]([CH2:20][CH3:21])[cH:19]3)[cH:4][cH:5][cH:6][cH:7]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 962Water3×HCID 6212ChloroformHCID 24479Stannous ChlorideHCID 312751,4-DioxaneHCID 197871684-(2-Chlorophenyl)-2-ethyl-5-nitrothieno[2,3-b]pyridine

Product 1

HCID 197871805-Amino-4-(2-chlorophenyl)-2-ethylthieno[2,3-b]pyridine

Sources & evidence

ORD record
ord-584825bbdc1f48cabbd2ac7e7f762859
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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