5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → 4-Fluoro-3'-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-2-carbonitrile
Reaction equation
[Cl:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([C:12]([F:13])([F:14])[F:15])[n:7][c:8]2[n:9][cH:10][cH:11]1.[F:16][c:17]1[cH:18][c:19]([C:38]#[N:39])[c:20](-[c:23]2[cH:24][c:25]([B:29]3[O:30][C:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[O:37]3)[cH:26][cH:27][cH:28]2)[cH:21][cH:22]1>>[c:2]1(-[c:25]2[cH:24][c:23](-[c:20]3[c:19]([C:38]#[N:39])[cH:18][c:17]([F:16])[cH:22][cH:21]3)[cH:28][cH:27][cH:26]2)[c:3]2[cH:4][cH:5][c:6]([C:12]([F:13])([F:14])[F:15])[n:7][c:8]2[n:9][cH:10][cH:11]1Participants
3
Sources & evidence
- ORD record
- ord-0be7fa61ec934e989929793066ce2516
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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