Potassium Cation → 4-(4-Iodo-phenyl)-1-(3,3,3-trifluoro-propyl)-piperidine-4-carbonitrile

HRID 954122Notes

Reaction equation

HRID 954122 reaction equation
[CH3:29][C:30]#[N:31].[CH3:32][CH2:33][O:34][C:35]([CH3:36])=[O:37].[F:16][C:17]([CH2:18][CH2:19][Br:20])([F:21])[F:22].[I:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:14]#[N:15])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:6][cH:7]1.[K+:23].[K+:24].[O-:25][C:26]([O-:27])=[O:28]>>[I:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:14]#[N:15])[CH2:9][CH2:10][N:11]([CH2:19][CH2:18][C:17]([F:16])([F:21])[F:22])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 224903724-(4-Iodo-phenyl)-piperidine-4-carbonitrile

Product 1

HCID 224903434-(4-Iodo-phenyl)-1-(3,3,3-trifluoro-propyl)-piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-1a1cc622cc8f400f8cbbcc1533a67656
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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