Phosphorus oxychloride → Ethyl 4-chloro-7-fluoroquinoline-3-carboxylate

HRID 954144Notes

Reaction equation

HRID 954144 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([OH:17])[c:7]([C:12](=[O:13])[O:14][CH2:15][CH3:16])[cH:8][n:9][c:10]2[cH:11]1.[P:18]([Cl:19])([Cl:20])([Cl:21])=[O:22]>>[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([Cl:20])[c:7]([C:12](=[O:13])[O:14][CH2:15][CH3:16])[cH:8][n:9][c:10]2[cH:11]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178469609Ethyl 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product 1

HCID 14219731Ethyl 4-chloro-7-fluoroquinoline-3-carboxylate

Sources & evidence

ORD record
ord-6e44bab5c4904fdcaef9b0fd95da930d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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