Dichloromethane → 6-Chloro-4-iodopyridin-3-amine

HRID 954178Notes

Reaction equation

[Cl:24][CH2:25][Cl:26].[Cl:8][c:9]1[cH:10][c:11]([I:23])[c:12]([NH:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[cH:13][n:14]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[cH:10][c:11]([I:23])[c:12]([NH2:15])[cH:13][n:14]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 53415320tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate

Product 1

HCID 184070406-Chloro-4-iodopyridin-3-amine

Sources & evidence

ORD record: ord-bbd20cbaf1d141d1baae0c6f77a5626b
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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