Acetate → Methyl 4'-fluoro-1,1'-biphenyl-4-carboxylate

HRID 954538Notes

Reaction equation

HRID 954538 reaction equation
[C:33]([O-:34])(=[O:35])[CH3:36].[C:38]([O-:39])(=[O:40])[CH3:41].[F:12][c:13]1[cH:14][cH:15][c:16]([B:19]([OH:20])[OH:21])[cH:17][cH:18]1.[I:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1.[K+:22].[K+:23].[O-:24][C:25]([O-:26])=[O:27].[O:28]=[CH:29][N:30]([CH3:31])[CH3:32].[Pd+2:37]>>[c:2]1(-[c:16]2[cH:15][cH:14][c:13]([F:12])[cH:18][cH:17]2)[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 69273Methyl 4-iodobenzoateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2856454-Fluorophenylboronic acid

Product 1

HCID 1394448Methyl 4'-fluoro-1,1'-biphenyl-4-carboxylate

Sources & evidence

ORD record
ord-2c2952e753b54f9d9bd0fa7a4d2087e0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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