Hydrochloric Acid → N4'-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazoline]-2',4'-diamine

HRID 954713Notes

Reaction equation

HRID 954713 reaction equation
[CH3:1][c:2]1[cH:3][cH:4][c:5]([S:6]([O:7][c:12]2[n:13][c:14]([NH2:26])[n:15][c:16]3[c:17]2[CH2:18][CH2:19][CH2:20][C:21]32[CH2:22][CH2:23][CH2:24][CH2:25]2)(=[O:8])=[O:9])[cH:10][cH:11]1.[ClH:27].[ClH:28].[NH2:29][CH2:30][CH2:31][NH:32][c:33]1[n:34][c:35]([NH2:39])[n:36][cH:37][cH:38]1>>[c:12]1([NH:29][CH2:30][CH2:31][NH:32][c:33]2[n:34][c:35]([NH2:39])[n:36][cH:37][cH:38]2)[n:13][c:14]([NH2:26])[n:15][c:16]2[c:17]1[CH2:18][CH2:19][CH2:20][C:21]21[CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 498566384-N-(2-aminoethyl)pyrimidine-2,4-diamineHCID 866343332'-amino-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazolin]-4'-yl 4-methylbenzenesulfonate

Product 1

HCID 86638146N4'-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazoline]-2',4'-diamine

Sources & evidence

ORD record
ord-1cf222142283498788ad80f5a9d1c7e5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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