Dichloromethane → 2-Bromo-4-methyl-thiazole-5-carboxylic acid benzylamide

HRID 954807Notes

Reaction equation

HRID 954807 reaction equation
[Br:1][c:2]1[s:3][c:4]([C:8](=[O:9])[OH:10])[c:5]([CH3:7])[n:6]1.[CH:11]([N:12]([CH:13]([CH3:14])[CH3:15])[CH2:16][CH3:17])([CH3:18])[CH3:19].[Cl:55][CH2:56][Cl:57].[NH2:47][CH2:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1.[P-:20]([F:21])([F:22])([F:23])([F:24])([F:25])[F:26].[n:27]1([O:28][P+:29]([N:30]([CH3:31])[CH3:32])([N:33]([CH3:34])[CH3:35])[N:36]([CH3:37])[CH3:38])[c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]2[n:45][n:46]1>>[Br:1][c:2]1[s:3][c:4]([C:8](=[O:10])[NH:47][CH2:48][c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:5]([CH3:7])[n:6]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 7504BenzylamineHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 28240582-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid

Product 1

HCID 579593962-Bromo-4-methyl-thiazole-5-carboxylic acid benzylamide

Sources & evidence

ORD record
ord-281b4b2540aa4b2bb6990b84568da7af
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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