Acetate → [2-(2,4-Difluoro-phenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone
Reaction equation
[C:74](=[O:75])([OH:76])[O-:77].[CH2:79]([CH2:80][O:81][CH3:82])[O:83][CH3:84].[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:6][cH:7][c:8]([O:30][S:31]([C:32]([F:33])([F:34])[F:35])(=[O:36])=[O:37])[c:9]([C:13]([c:14]3[cH:15][cH:16][c:17]([O:20][CH2:21][CH2:22][N:23]4[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]4)[cH:18][cH:19]3)=[O:29])[c:10]2[cH:11][cH:12]1.[F:38][c:39]1[c:40]([B:46]([OH:47])[OH:48])[cH:41][cH:42][c:43]([F:45])[cH:44]1.[Na+:49].[Na+:50].[Na+:78].[O-:51][C:52](=[O:53])[O-:54].[O-:86][C:87]([CH3:88])=[O:89].[O-:90][C:91]([CH3:92])=[O:93].[Pd+2:85].[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:6][cH:7][c:8](-[c:40]3[c:39]([F:38])[cH:44][c:43]([F:45])[cH:42][cH:41]3)[c:9]([C:13]([c:14]3[cH:15][cH:16][c:17]([O:20][CH2:21][CH2:22][N:23]4[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]4)[cH:18][cH:19]3)=[O:29])[c:10]2[cH:11][cH:12]1Participants
10
Reactant 9
HCID 175Acetate2×
HCID 769Bicarbonate Ion
HCID 923Sodium ion3×
HCID 80711,2-Dimethoxyethane
HCID 11776Triphenylphosphine
HCID 19660Carbonate Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 27343342,4-Difluorophenylboronic acid
HCID 11685250Trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)benzoyl]-naphthalen-2-yl esterProduct 1
Sources & evidence
- ORD record
- ord-ab851050673e4984955101c60a2fafec
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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