Ammonium → tert-butyl N-[2-[(5-chloro-1H-indole-2-carbonyl)amino]-5-(hydroxymethyl)cyclohexyl]carbamate

HRID 954911Notes

Reaction equation

HRID 954911 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH:10]([NH:20][C:21](=[O:22])[c:23]2[nH:24][c:25]3[cH:26][cH:27][c:28]([Cl:32])[cH:29][c:30]3[cH:31]2)[CH2:11][CH2:12][CH:13]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[CH2:14]1.[CH2:40]([Li:41])[CH:42]([CH3:43])[CH3:44].[CH3:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38].[Cl-:45].[Cl:47][CH2:48][Cl:49].[H-:39].[NH4+:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH:10]([NH:20][C:21](=[O:22])[c:23]2[nH:24][c:25]3[cH:26][cH:27][c:28]([Cl:32])[cH:29][c:30]3[cH:31]2)[CH2:11][CH2:12][CH:13]([CH2:15][OH:16])[CH2:14]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 6344DichloromethaneHCID 8058HexaneHCID 166653HydrideHCID 68590514ethyl 4-[(5-chloro-1H-indole-2-carbonyl)amino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylateHCID 178506859HCID 178506859, compound

Product 1

HCID 68604678tert-butyl N-[2-[(5-chloro-1H-indole-2-carbonyl)amino]-5-(hydroxymethyl)cyclohexyl]carbamate

Sources & evidence

ORD record
ord-8004c5be5d054add89db1b4bc4ced959
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…