Dichloromethane → N-(4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amino]-benzamide

HRID 955031Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([NH:20][C:21]([c:22]3[c:23]([NH:28][CH2:29][c:30]4[cH:31][nH:32][c:33]5[n:34][cH:35][cH:36][cH:37][c:38]45)[cH:24][cH:25][cH:26][cH:27]3)=[O:39])[cH:13][cH:14][c:15]2[C:16]([CH3:18])([CH3:19])[CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[NH:8]1[CH2:9][c:10]2[cH:11][c:12]([NH:20][C:21]([c:22]3[c:23]([NH:28][CH2:29][c:30]4[cH:31][nH:32][c:33]5[n:34][cH:35][cH:36][cH:37][c:38]45)[cH:24][cH:25][cH:26][cH:27]3)=[O:39])[cH:13][cH:14][c:15]2[C:16]([CH3:18])([CH3:19])[CH2:17]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 695113924,4-Dimethyl-7-{2-[(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amino]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 59017450N-(4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amino]-benzamide

Sources & evidence

ORD record: ord-f70cc3b6536242eb8f8aed9c0f2e976c
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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