1-Butanol → 2-Methyl-4-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]hexan-3-ol

HRID 955048Notes

Reaction equation

HRID 955048 reaction equation
[CH2:40]([OH:41])[CH2:42][CH2:43][CH3:44].[CH3:45][S:46]([CH3:47])=[O:48].[CH:22]([N:23]([CH2:24][CH3:25])[CH:26]([CH3:27])[CH3:28])([CH3:29])[CH3:30].[F:1][c:2]1[n:3][c:4]([NH:14][CH2:15][c:16]2[cH:17][n:18][cH:19][cH:20][cH:21]2)[c:5]2[n:6][cH:7][n:8]([CH:11]([CH3:12])[CH3:13])[c:9]2[n:10]1.[NH2:31][CH:32]([CH:33]([CH:34]([CH3:35])[CH3:36])[OH:37])[CH2:38][CH3:39]>>[c:2]1([NH:31][CH:32]([CH:33]([CH:34]([CH3:35])[CH3:36])[OH:37])[CH2:38][CH3:39])[n:3][c:4]([NH:14][CH2:15][c:16]2[cH:17][n:18][cH:19][cH:20][cH:21]2)[c:5]2[n:6][cH:7][n:8]([CH:11]([CH3:12])[CH3:13])[c:9]2[n:10]1

Participants

6

Reactant 5

HCID 2631-ButanolHCID 679Dimethyl SulfoxideHCID 446743-Hexanol, 4-amino-2-methyl-HCID 81531DiisopropylethylamineHCID 115220602-fluoro-9-isopropyl-N-(pyridin-3-ylmethyl)-9H-purin-6-amine

Product 1

HCID 693019792-Methyl-4-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]hexan-3-ol

Sources & evidence

ORD record
ord-ce374c1f49a040ba90c8ca108665f60a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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