Sodium ion → tert-butyl (3RS,4RS)-4-(4-fluorophenyl)-3-(4-methoxy-benzyloxy)-piperidine-1-carboxylate

HRID 955061Notes

Reaction equation

HRID 955061 reaction equation
[CH3:22][O:23][c:24]1[cH:25][cH:26][c:27]([CH2:28][Cl:29])[cH:30][cH:31]1.[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([OH:21])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[H-:32].[Na+:33]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:21][CH2:28][c:27]3[cH:26][cH:25][c:24]([O:23][CH3:22])[cH:31][cH:30]3)[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 699934-Methyloxybenzyl chlorideHCID 166653HydrideHCID 45074236Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 86604390tert-butyl (3RS,4RS)-4-(4-fluorophenyl)-3-(4-methoxy-benzyloxy)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-9dd0bbb21bbc44458da35f5a0bb77f17
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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