Pyridine → 1-Benzyl 2-ethyl 4-[(4-methylbenzenesulfonyl)oxy]pyrrolidine-1,2-dicarboxylate

HRID 955066Notes

Reaction equation

HRID 955066 reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([CH:5]1[N:6]([C:11](=[O:12])[O:13][CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[CH2:7][CH:8]([OH:10])[CH2:9]1)=[O:21].[Cl:33][CH:34]([Cl:35])[Cl:36].[Cl:37][CH2:38][Cl:39].[c:22]1([CH3:32])[cH:23][cH:24][c:25]([S:28](=[O:29])(=[O:30])[Cl:31])[cH:26][cH:27]1.[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]1[N:6]([C:11](=[O:12])[O:13][CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[CH2:7][CH:8]([O:10][S:28]([c:25]2[cH:24][cH:23][c:22]([CH3:32])[cH:27][cH:26]2)(=[O:29])=[O:30])[CH2:9]1)=[O:21]

Participants

6

Reactant 5

HCID 1049PyridineHCID 6212ChloroformHCID 6344DichloromethaneHCID 73974-Toluenesulfonyl chlorideHCID 146545891-Cbz-4(R)-hydroxypyrrolidine-2-carboxylic acid ethyl ester

Product 1

HCID 148045991-Benzyl 2-ethyl 4-[(4-methylbenzenesulfonyl)oxy]pyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-4c72012f0cbc417c9f5d9111c8f964c3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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