Dichloromethane → 6-{1-[6-(6-Piperazin-1-ylpyridin-3-yl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline
Reaction equation
[CH2:49]([Cl:50])[Cl:51].[OH:42][C:43]([C:44]([F:45])([F:46])[F:47])=[O:48].[n:1]1[cH:2][cH:3][cH:4][c:5]2[cH:6][c:7]([C:11]3([c:14]4[cH:15][n:16][c:17]5[n:18]4[cH:19][c:20](-[c:23]4[cH:24][cH:25][c:26]([N:29]6[CH2:30][CH2:31][N:32]([C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:33][CH2:34]6)[n:27][cH:28]4)[cH:21][n:22]5)[CH2:12][CH2:13]3)[cH:8][cH:9][c:10]12>>[n:1]1[cH:2][cH:3][cH:4][c:5]2[cH:6][c:7]([C:11]3([c:14]4[cH:15][n:16][c:17]5[n:18]4[cH:19][c:20](-[c:23]4[cH:24][cH:25][c:26]([N:29]6[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]6)[n:27][cH:28]4)[cH:21][n:22]5)[CH2:12][CH2:13]3)[cH:8][cH:9][c:10]12Participants
4
Sources & evidence
- ORD record
- ord-ca7b9bbf30e042ed889538c36d885953
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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