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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 955204Generated: October 27, 2026

Bicarbonate Ion → 6-{[(3-Fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/955204

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBicarbonate IonHCID 769—
ReactantSodium ionHCID 923—
Reactant2-Thiophenecarbonyl chlorideHCID 78928—
ReactantDiisopropylethylamineHCID 81531—
Reactant6-[(3-Fluoro-4-morpholin-4-yl-phenylamino)-methyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl esterHCID 69038711—
Product6-{[(3-Fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl esterHCID 69036655—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-560775f44eca4c96845fa0f4f7e5a5fb
Source noteValidation data from https://doi.org/10.1039/C8SC04228D